SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
TMEM2



General Information
Gene Symbol:   
TMEM2
Protein name:   
Hyaluronoglucosaminidase
Enzyme Class:   
Glycosidase
CAZy Family:   
E.C. No:   
3.2.1.35
Organs:   
Reaction (SNFG):   

...GlcNAc(b1-4)GlcA(a1-3) → ...GlcNAc(b1-4)&GlcA(a1-3)
Reaction (IUBMB):   
No specified reaction.
About

• Random hydrolysis of beta(1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues.
• Could play a co-operative role with HYAL2 to facilitate HA degradation at cell surface.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
A0A024R229 
NCBI GeneID:   
23670
GlyMap GeneID:   
23670
DNA aRefSeq:   
NM_013390.2 
Protein RefSeq:   
NP_037522.1 
BRENDA:   
Kinetic info.
OMIM number:   
-
GeneCards database:   
TMEM2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     ...GlcNAc(b1-4)GlcA(a1-3)
Product:  
     ...GlcNAc(b1-4)&GlcA(a1-3)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 50 40 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data