Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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• Acts on some glycolipids and also O-glycans.
• ST6GalNAc-III, -V, and -VI can synthesize GD1-alpha from GM1b in gangliosides, with activity of ST6GalNAc-IV toward this substrate being poorer.
• ST6GalNAc-III exhibits relatively poor activity for GD1a [NeuAc(α2-3)Gal(β1-3)GalNAc(β1-4)[NeuAc(α2-3)]Gal(β1-4)Glc(β1-?)Cer] and GT1b [NeuAc(α2-3)Gal(β1-3)GalNAc(β1-4)[NeuAc(α2-8)NeuAc(α2-3)]Gal(β1-4)Glc(β1-?)Cer] substrates. ST6GalNAc-VI however prefers GD1a and GT1b.
ER | Cis- | Medial- | Trans- | TGN |
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ST6GALNAC3/hsa-miR-3115 |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AUUCAUUUUAAA
ACCCAUAA
...
3' UGGUUGAUCAUU UGGGUAU A |
8mer | 5665-5672 | -0.485 | 98.0 | -0.464 | 98.0 | noncon | |
5'...CUCAAUAUUCAC
ACCCAUAA
...
3' UGGUUGAUCAUU UGGGUAU A |
8mer | 1913-1920 | -0.322 | 94.0 | -0.322 | 96.0 | noncon |