SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ST3GAL6



General Information
Gene Symbol:   
ST3GAL6
Protein name:   
Type 2 lactosamine alpha-2,3-sialyltransferase
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT29
E.C. No:   
2.4.99.6
Organs:   
Reaction (SNFG):   
+
→
+ CMP
Reaction (IUBMB):   
No specified reaction.
About

• ST3Gal6 has high specificity for neolactotetraosylceramide (paragloboside, nLc4) and neolactohexaosylceramide (nLc6) as glycosphingolipid substrates.
• It shows preference for Gal1β,4GlcNAc and less for Galβ1,3GlcNAc.
• ST3Gal6 might have distinct role especially in the regulation of the synthesis of sialyl type II lactosamine on glycolipids. Preference on glycoproteins is under study. Enzyme can contribute to sLeX biosynthesis.

Related Pathway
KEGG ORTHOLOGY:   
K03792
KEGG Pathway:   
ko00601  ko01100 
Reactome:   
R-HSA-1912420
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9Y274 
NCBI GeneID:   
10402
GlyMap GeneID:   
10402
DNA aRefSeq:   
NM_001271145.1 
Protein RefSeq:   
NP_001258074.1 
BRENDA:   
Kinetic info.
OMIM number:   
607156
GeneCards database:   
ST3GAL6
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), O-linked (other), GSL
Compartment:  
     
Substrate:  
     Gal(b1-4)GlcNAc(b1-?)
Product:  
     NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    7.26e-05    (pmol/cell • hr)       KM:    2.60e+08    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4634 1092-1099 -0.646 96.0 -0.042 32.0 noncon
hsa-miR-637 490-497 -0.637 99.0 -0.336 97.0 noncon
hsa-miR-320e 135-142 -0.629 99.0 -0.629 99.0 noncon
hsa-miR-3529-5p 3800-3807 -0.619 99.0 -0.005 32.0 noncon
hsa-miR-7152-5p 196-203 -0.609 99.0 -0.448 99.0 noncon
hsa-miR-4733-3p 117-124 -0.604 99.0 -0.604 99.0 noncon
hsa-miR-5091 3083-3090 -0.591 98.0 -0.005 15.0 noncon
hsa-miR-876-3p 130-137 -0.586 99.0 -0.586 99.0 noncon
hsa-miR-379-5p 3800-3807 -0.585 99.0 -0.005 33.0 noncon
hsa-miR-21-5p 231-238 -0.562 99.0 -0.34 98.0 con
hsa-miR-5193 360-367 -0.555 99.0 -0.296 95.0 noncon
hsa-miR-590-5p 231-238 -0.55 99.0 -0.334 99.0 con
hsa-miR-144-3p 153-160 -0.538 99.0 -0.538 99.0 noncon
hsa-miR-138-5p 133-139 -0.511 98.0 -0.511 98.0 con
hsa-miR-4304 2368-2375 -0.509 96.0 -0.004 15.0 noncon
hsa-miR-6751-3p 1566-1573 -0.49 99.0 -0.018 58.0 noncon
hsa-miR-548o-3p 207-214 -0.486 99.0 -0.313 99.0 noncon
hsa-miR-200a-3p 28-35 -0.477 99.0 -0.477 99.0 noncon
hsa-miR-141-3p 28-35 -0.477 99.0 -0.477 99.0 noncon
hsa-miR-4648 1669-1676 -0.473 99.0 -0.018 50.0 noncon
hsa-miR-4780 3181-3188 -0.459 99.0 -0.004 25.0 noncon
hsa-miR-1323 207-214 -0.457 99.0 -0.296 99.0 noncon
hsa-miR-6863 258-264 -0.451 97.0 -0.245 87.0 noncon
hsa-miR-1293 2577-2584 -0.449 99.0 -0.004 26.0 noncon
hsa-miR-1199-5p 1566-1573 -0.445 99.0 -0.017 60.0 noncon
hsa-miR-133a-5p 1649-1656 -0.44 98.0 -0.016 37.0 noncon
hsa-miR-4742-5p 740-747 -0.438 99.0 -0.03 65.0 noncon
hsa-miR-188-5p 294-301 -0.433 99.0 -0.236 96.0 noncon
hsa-miR-630 616-623 -0.428 98.0 -0.03 53.0 noncon
hsa-miR-581 3589-3596 -0.424 98.0 -0.004 37.0 noncon
hsa-miR-412-3p 1373-1380 -0.42 98.0 -0.029 64.0 noncon
hsa-miR-6754-3p 1373-1380 -0.41 98.0 -0.028 67.0 noncon
hsa-miR-410-5p 1510-1517 -0.408 97.0 -0.015 41.0 noncon
hsa-miR-553 2850-2857 -0.403 97.0 -0.004 16.0 noncon
hsa-miR-6879-3p 1114-1121 -0.403 96.0 -0.028 56.0 noncon
hsa-miR-127-5p 3649-3656 -0.402 98.0 -0.004 37.0 noncon
hsa-miR-323b-5p 1510-1517 -0.4 97.0 -0.015 41.0 noncon
hsa-miR-494-5p 1510-1517 -0.4 97.0 -0.015 41.0 noncon
hsa-miR-4661-5p 234-240 -0.399 97.0 -0.247 93.0 noncon
hsa-miR-520a-5p 441-448 -0.391 98.0 -0.214 95.0 noncon
hsa-miR-7843-3p 1827-1834 -0.391 98.0 -0.015 52.0 noncon
hsa-miR-593-5p 2543-2550 -0.389 96.0 -0.003 19.0 noncon
hsa-miR-3064-3p 418-425 -0.388 96.0 -0.213 92.0 noncon
hsa-miR-423-5p 3506-3512 -0.384 97.0 -0.003 28.0 noncon
hsa-miR-3184-5p 3506-3512 -0.384 97.0 -0.003 28.0 noncon
hsa-miR-4483 2577-2584 -0.381 99.0 -0.003 41.0 noncon
hsa-miR-500a-3p 1703-1710 -0.38 97.0 -0.015 43.0 noncon
hsa-miR-4476 1317-1324 -0.38 99.0 -0.027 70.0 noncon
hsa-miR-6818-5p 2004-2011 -0.38 99.0 -0.015 46.0 noncon
hsa-miR-6841-5p 2044-2050 -0.377 96.0 -0.014 39.0 noncon
hsa-miR-6839-3p 3525-3532 -0.376 97.0 -0.003 34.0 noncon
hsa-miR-525-5p 441-448 -0.375 98.0 -0.206 94.0 noncon
hsa-miR-6876-5p 1317-1324 -0.372 99.0 -0.026 70.0 noncon
hsa-miR-653-5p 3819-3826 -0.371 99.0 -0.003 38.0 con
hsa-miR-6866-3p 294-301 -0.368 99.0 -0.202 97.0 noncon
hsa-miR-4768-3p 479-486 -0.366 99.0 -0.201 97.0 noncon
hsa-miR-548ao-5p 273-280 -0.365 98.0 -0.201 94.0 noncon
hsa-miR-124-5p 2295-2302 -0.365 97.0 -0.003 22.0 noncon
hsa-miR-3118 2516-2523 -0.361 97.0 -0.003 30.0 noncon
hsa-miR-549a 1416-1423 -0.356 97.0 -0.025 50.0 noncon
hsa-miR-199b-5p 1483-1490 -0.354 96.0 -0.014 52.0 noncon
hsa-miR-4764-5p 3775-3782 -0.354 96.0 -0.003 26.0 noncon
hsa-miR-199a-5p 1483-1490 -0.354 96.0 -0.014 52.0 noncon
hsa-miR-644a 2474-2481 -0.353 96.0 -0.003 38.0 noncon
hsa-miR-1324 104-110 -0.353 99.0 -0.353 99.0 noncon
hsa-miR-134-5p 2516-2523 -0.353 97.0 -0.003 31.0 noncon
hsa-miR-1911-3p 116-122 -0.348 97.0 -0.348 98.0 noncon
hsa-miR-4645-3p 102-108 -0.346 97.0 -0.346 98.0 noncon
hsa-miR-1537-5p 2961-2968 -0.344 95.0 -0.003 17.0 noncon
hsa-miR-548ax 273-280 -0.341 98.0 -0.188 93.0 noncon
hsa-miR-431-5p 2268-2275 -0.338 97.0 -0.003 43.0 con
hsa-miR-152-5p 2619-2626 -0.338 96.0 -0.003 27.0 noncon
hsa-miR-5708 2411-2417 -0.335 90.0 -0.003 12.0 noncon
hsa-miR-4327 3161-3168 -0.335 97.0 -0.003 25.0 noncon
hsa-miR-27b-3p 147-153 -0.334 97.0 -0.334 98.0 con
hsa-miR-27a-3p 147-153 -0.334 97.0 -0.334 98.0 con
hsa-miR-1258 877-884 -0.333 94.0 -0.024 35.0 noncon
hsa-miR-623 3182-3189 -0.332 98.0 -0.003 39.0 noncon
hsa-miR-6516-5p 49-55 -0.332 98.0 -0.332 98.0 noncon
hsa-miR-3121-5p 3166-3173 -0.331 97.0 -0.003 47.0 noncon
hsa-miR-6751-5p 489-495 -0.33 96.0 -0.183 88.0 noncon
hsa-miR-4738-5p 2097-2103 -0.329 92.0 -0.003 19.0 noncon
hsa-miR-7974 1772-1779 -0.327 95.0 -0.013 35.0 noncon
hsa-miR-323b-5p 485-491 -0.325 94.0 -0.18 87.0 noncon
hsa-miR-410-5p 485-491 -0.325 94.0 -0.18 87.0 noncon
hsa-miR-510-3p 3820-3827 -0.324 99.0 -0.003 56.0 noncon
hsa-miR-6835-5p 489-495 -0.324 93.0 -0.179 76.0 noncon
hsa-miR-4456 132-138 -0.323 96.0 -0.323 97.0 noncon
hsa-miR-1185-2-3p 156-162 -0.321 99.0 -0.321 99.0 noncon
hsa-miR-1185-1-3p 156-162 -0.321 99.0 -0.321 99.0 noncon
hsa-miR-6728-3p 2630-2637 -0.317 98.0 -0.003 41.0 noncon
hsa-miR-6803-5p 489-495 -0.316 95.0 -0.175 87.0 noncon
hsa-miR-2681-3p 508-514 -0.313 98.0 -0.174 94.0 noncon
hsa-miR-218-2-3p 505-511 -0.311 97.0 -0.173 93.0 noncon
hsa-miR-554 2923-2930 -0.307 95.0 -0.003 39.0 noncon
hsa-miR-1226-3p 389-395 -0.305 96.0 -0.169 92.0 noncon
hsa-miR-4445-5p 3567-3574 -0.304 95.0 -0.003 28.0 noncon
hsa-miR-494-5p 485-491 -0.303 93.0 -0.168 86.0 noncon
hsa-miR-5579-3p 232-238 -0.301 97.0 -0.189 94.0 noncon
hsa-miR-27b-5p 472-478 -0.301 97.0 -0.167 90.0 noncon
hsa-miR-4673 115-121 -0.299 98.0 -0.299 98.0 noncon
hsa-miR-7851-3p 1021-1028 -0.299 95.0 -0.021 49.0 noncon
hsa-miR-4713-5p 2394-2401 -0.299 96.0 -0.003 22.0 noncon
hsa-miR-362-5p 3443-3450 -0.298 98.0 -0.003 35.0 noncon
hsa-miR-654-3p 3258-3265 -0.298 98.0 -0.003 37.0 noncon
hsa-miR-3162-3p 1358-1364 -0.298 91.0 -0.021 49.0 noncon
hsa-miR-500b-5p 3443-3450 -0.298 98.0 -0.003 36.0 noncon
hsa-miR-3065-3p 1842-1848 -0.297 97.0 -0.012 62.0 noncon
hsa-miR-6795-3p 1908-1915 -0.296 98.0 -0.012 43.0 noncon
hsa-miR-376a-5p 2053-2060 -0.296 98.0 -0.012 73.0 noncon
hsa-let-7f-2-3p 156-162 -0.295 98.0 -0.295 99.0 noncon
hsa-miR-4290 1920-1927 -0.294 90.0 -0.012 37.0 noncon
hsa-miR-889-5p 1774-1781 -0.294 96.0 -0.012 43.0 noncon
hsa-miR-6868-3p 706-713 -0.294 96.0 -0.021 60.0 noncon
hsa-miR-4667-5p 491-497 -0.293 96.0 -0.163 87.0 noncon
hsa-miR-4688 3505-3511 -0.289 94.0 -0.003 15.0 noncon
hsa-miR-4692 114-120 -0.287 97.0 -0.287 98.0 noncon
hsa-miR-4764-5p 2936-2943 -0.287 93.0 -0.003 25.0 noncon
hsa-miR-891a-3p 2472-2479 -0.284 95.0 -0.003 37.0 noncon
hsa-miR-3606-5p 2310-2316 -0.283 95.0 -0.003 23.0 noncon
hsa-miR-670-3p 3671-3678 -0.282 97.0 -0.003 31.0 noncon
hsa-miR-4432 3471-3478 -0.282 97.0 -0.003 48.0 noncon
hsa-miR-891a-3p 2545-2552 -0.28 95.0 -0.002 37.0 noncon
hsa-miR-3150a-5p 1393-1399 -0.28 98.0 -0.02 60.0 noncon
hsa-miR-3150b-5p 1393-1399 -0.28 98.0 -0.02 59.0 noncon
hsa-miR-4645-5p 115-121 -0.278 97.0 -0.278 98.0 noncon
hsa-miR-6734-5p 1760-1766 -0.277 91.0 -0.011 36.0 noncon
hsa-miR-7152-5p 3112-3119 -0.276 97.0 -0.002 45.0 noncon
hsa-miR-6733-3p 1882-1889 -0.275 96.0 -0.011 59.0 noncon
hsa-miR-4432 3148-3155 -0.27 97.0 -0.002 48.0 noncon
hsa-miR-101-3p.2 154-160 -0.27 98.0 -0.27 98.0 noncon
hsa-miR-6743-5p 3505-3511 -0.268 93.0 -0.002 15.0 noncon
hsa-miR-1248 705-712 -0.268 96.0 -0.019 58.0 noncon
hsa-miR-455-3p.2 49-55 -0.265 97.0 -0.265 98.0 noncon
hsa-miR-6865-3p 1533-1539 -0.264 94.0 -0.01 52.0 noncon
hsa-miR-4435 946-953 -0.263 94.0 -0.019 54.0 noncon
hsa-miR-6890-3p 541-547 -0.262 97.0 -0.019 74.0 noncon
hsa-miR-8076 3779-3786 -0.26 95.0 -0.002 24.0 noncon
hsa-miR-3180-5p 442-449 -0.26 97.0 -0.145 93.0 noncon
hsa-miR-4252 3454-3461 -0.26 97.0 -0.002 37.0 noncon
hsa-miR-4303 1567-1574 -0.259 96.0 -0.01 62.0 noncon
hsa-miR-508-3p 3568-3574 -0.258 94.0 -0.002 23.0 noncon
hsa-miR-508-3p 2320-2326 -0.256 94.0 -0.002 23.0 noncon
hsa-miR-4514 114-120 -0.255 96.0 -0.255 97.0 noncon
hsa-miR-4254 3556-3563 -0.254 97.0 -0.002 42.0 noncon
hsa-miR-6853-3p 2293-2300 -0.253 94.0 -0.002 28.0 noncon
hsa-miR-8089 491-497 -0.253 94.0 -0.142 85.0 noncon
hsa-miR-526b-5p 702-709 -0.252 96.0 -0.018 59.0 noncon
hsa-miR-363-5p 2578-2584 -0.251 92.0 -0.002 19.0 noncon
hsa-miR-1206 2905-2911 -0.251 95.0 -0.002 29.0 noncon
hsa-miR-4755-3p 1239-1245 -0.25 92.0 -0.018 52.0 noncon