Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• Strict specificity for Type 3 lactosamine, predominantly on O-glycans.
• Does not add sialic acid to Galβ1,4GlcNAc (Type II).
• Although it can sialylate asialo-GM1 in vitro, mouse data suggest that it may not be acting on ganglioside substrates in vivo.
• Expressed in medullary area of thymus which is ST3Gal1+/PNA-1. In contrast cortical area is PNA+ and ST3Gal1-.
• GT-A like fold in structure, but lacking the DxD motif that binds metal ions.
• In human, ST3GAL1 is highly expressed in broadly expressed in the heart, placenta, skeletal muscle, kidney, pancreas, liver, spleen, and peripheral blood leukocytes.
• Enzyme is expressed in trans Golgi and also medial Golgi.
• ST3GAL1 deficiency in mouse decreased 90 % CD8+ T cells due to increased apoptosis, but not CD4+ T cells in the blood, lymph node, and spleen. In addition, platelet counts are decreased in ST3GAL1-deficient mice compared to wild-type mice, and platelet size is enhanced.