SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35C1



General Information
Gene Symbol:   
SLC35C1
Protein name:   
GDP-fucose transporter 1
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

GPF-Fuc [cyto] → GPF-Fuc [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• Transports only GDP-Fuc (synthesized in cytoplasm) to the Golgi lumen
• Golgi fucosylation was strongly impaired in SLC35C1-deficient patients and knockout mouse, fucosylation in the ER was not extensively affected. Thus, there may be other fucose transporters in ER

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-5619078
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q96A29 
NCBI GeneID:   
55343
GlyMap GeneID:   
55343
DNA aRefSeq:   
NM_001145265.1 
Protein RefSeq:   
NP_001138737.1 
BRENDA:   
Kinetic info.
OMIM number:   
605881
GeneCards database:   
SLC35C1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     GPF-Fuc [cyto]
Product:  
     GPF-Fuc [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4774-5p 208-215 -0.521 99.0 -0.521 99.0 noncon
hsa-miR-6871-3p 110-117 -0.504 99.0 -0.504 99.0 noncon
hsa-miR-6762-5p 1054-1061 -0.442 97.0 -0.349 95.0 noncon
hsa-miR-4320 1669-1676 -0.436 99.0 -0.345 98.0 noncon
hsa-miR-6845-5p 1054-1061 -0.434 97.0 -0.343 95.0 noncon
hsa-miR-1289 1288-1295 -0.431 97.0 -0.341 96.0 noncon
hsa-miR-4792 624-631 -0.43 98.0 -0.34 97.0 noncon
hsa-miR-5698 711-718 -0.404 94.0 -0.32 92.0 noncon
hsa-miR-4723-5p 711-718 -0.396 94.0 -0.314 91.0 noncon
hsa-miR-6870-5p 711-718 -0.396 94.0 -0.314 91.0 noncon
hsa-miR-182-5p 219-226 -0.394 98.0 -0.394 98.0 con
hsa-miR-4757-5p 1168-1175 -0.391 98.0 -0.31 97.0 noncon
hsa-miR-7111-5p 711-718 -0.388 93.0 -0.308 90.0 noncon
hsa-miR-6762-5p 1342-1348 -0.382 95.0 -0.303 93.0 noncon
hsa-miR-4762-3p 174-181 -0.375 99.0 -0.375 99.0 noncon
hsa-miR-615-5p 80-87 -0.372 96.0 -0.372 96.0 noncon
hsa-miR-4266 1349-1356 -0.368 96.0 -0.292 95.0 noncon
hsa-miR-1246 1671-1678 -0.366 98.0 -0.291 98.0 noncon
hsa-miR-6845-5p 1342-1348 -0.358 95.0 -0.285 92.0 noncon
hsa-miR-6874-5p 1333-1340 -0.356 97.0 -0.283 96.0 noncon
hsa-miR-6802-3p 1519-1525 -0.346 96.0 -0.275 95.0 noncon
hsa-miR-6895-5p 416-423 -0.345 97.0 -0.275 96.0 noncon
hsa-miR-4488 1315-1322 -0.344 95.0 -0.274 92.0 noncon
hsa-miR-4697-5p 1315-1322 -0.344 95.0 -0.274 92.0 noncon
hsa-miR-6749-3p 534-541 -0.34 96.0 -0.271 95.0 noncon
hsa-miR-1237-5p 1315-1322 -0.339 95.0 -0.27 92.0 noncon
hsa-miR-218-1-3p 188-194 -0.337 96.0 -0.337 97.0 noncon
hsa-miR-4725-5p 695-702 -0.331 96.0 -0.264 94.0 noncon
hsa-miR-562 114-121 -0.331 98.0 -0.331 98.0 noncon
hsa-miR-4651 920-927 -0.323 90.0 -0.257 86.0 noncon
hsa-miR-708-5p 1076-1083 -0.313 97.0 -0.25 96.0 noncon
hsa-miR-218-1-3p 152-158 -0.313 95.0 -0.313 96.0 noncon
hsa-miR-6744-3p 1168-1175 -0.313 98.0 -0.25 97.0 noncon
hsa-miR-28-5p 1076-1083 -0.313 97.0 -0.25 96.0 noncon
hsa-miR-6757-3p 192-198 -0.308 98.0 -0.308 98.0 noncon
hsa-miR-6825-5p 857-864 -0.307 90.0 -0.245 86.0 noncon
hsa-miR-4309 1289-1296 -0.307 97.0 -0.245 96.0 noncon
hsa-miR-7847-3p 325-332 -0.306 94.0 -0.244 92.0 noncon
hsa-miR-548al 1092-1098 -0.305 91.0 -0.243 90.0 noncon
hsa-miR-6801-3p 1395-1401 -0.295 94.0 -0.236 92.0 noncon
hsa-miR-6734-5p 1596-1602 -0.294 93.0 -0.235 91.0 noncon
hsa-miR-6862-3p 1371-1378 -0.292 95.0 -0.233 94.0 noncon
hsa-miR-6757-3p 156-162 -0.29 97.0 -0.29 98.0 noncon
hsa-miR-3657 1408-1415 -0.288 92.0 -0.23 92.0 noncon
hsa-miR-3139 1076-1083 -0.287 96.0 -0.229 95.0 noncon
hsa-miR-4474-3p 384-391 -0.286 94.0 -0.229 93.0 noncon
hsa-miR-3154 227-233 -0.284 97.0 -0.253 97.0 noncon
hsa-miR-3918 754-761 -0.284 95.0 -0.227 93.0 noncon
hsa-miR-124-5p 658-665 -0.282 94.0 -0.226 92.0 noncon
hsa-miR-6784-3p 1371-1378 -0.279 94.0 -0.223 93.0 noncon
hsa-miR-744-3p 353-360 -0.279 95.0 -0.223 94.0 noncon
hsa-miR-7106-3p 270-277 -0.278 93.0 -0.222 92.0 noncon
hsa-miR-3612 323-330 -0.275 95.0 -0.22 94.0 noncon
hsa-miR-6810-3p 1395-1401 -0.272 92.0 -0.218 91.0 noncon
hsa-miR-4490 209-215 -0.27 94.0 -0.27 96.0 noncon
hsa-miR-200a-3p 193-199 -0.268 97.0 -0.268 98.0 con
hsa-miR-650 323-330 -0.267 95.0 -0.214 94.0 noncon
hsa-miR-6776-3p 140-146 -0.267 95.0 -0.267 97.0 noncon
hsa-miR-6506-5p 1605-1612 -0.267 98.0 -0.214 98.0 noncon
hsa-miR-6780b-3p 663-670 -0.266 95.0 -0.213 95.0 noncon
hsa-miR-196a-3p 218-224 -0.264 92.0 -0.264 95.0 noncon
hsa-miR-7155-5p 82-89 -0.26 96.0 -0.26 97.0 noncon
hsa-miR-141-3p 193-199 -0.257 96.0 -0.257 97.0 con
hsa-miR-214-5p 349-356 -0.257 95.0 -0.206 95.0 noncon
hsa-miR-4423-5p 352-359 -0.256 92.0 -0.205 91.0 noncon
hsa-miR-1289 1184-1190 -0.255 90.0 -0.204 89.0 noncon
hsa-miR-3199 717-723 -0.251 91.0 -0.201 89.0 noncon