Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (firstname.lastname@example.org), Yusen Zhou (email@example.com) or Ted Groth (firstname.lastname@example.org).
|PAPS [Cyto]||→||PAPS [Golgi]|
• SLC35B2 and B3 transfer PAPS from the cytosol into the Golgi apparatus from the cytoplasm.
• PAPS is a universal sulfuryl donor for sulfation.
• Depending on cancer type, the expression of PAPST1 and PAPST2 can increase or decrease, resulting in increases or decreases in sulfation of GAGs, respectively.
• Decreased expression of PAPST1 and PAPST2 caused FGF signaling to decrease in colorectal cells.