Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• N-sulfoglucosamine sulfohydrolase removes sulfate from GlcNAc in lysosomes. Involved in the breakdown and recycling of GAGs.
• Deficiency in SGSH activity results in mucopolysaccharidosis type IIIA. This causes an accumulation of heparan sulfates. The disease causes seizures, which results in rapid neurodegeneration and death in late childhood.