GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
POGLUT2



General Information
Gene Symbol:   
POGLUT2
Protein name:   
Protein O-glucosyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT90
E.C. No:   
2.4.1.*
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Protein GlcTs POGLUT2 and POGLUT3 catalyzes O-Glc biosynthesis on serine residue between 3rd and 4th Cys in EGF domain of selected proteins: NOTCH1 and NOTCH3
• Such glycosylation occurs at the consensus sequence peptide C-X-N-T-X-G-S-F-X-C

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q6UW63 
NCBI GeneID:   
79070
GlyMap GeneID:   
79070
DNA aRefSeq:   
NM_001318732.1 
Protein RefSeq:   
NP_001305661.1 
BRENDA:   
Kinetic info.
OMIM number:   
611613
GeneCards database:   
POGLUT2
Enzyme Specificity
Glycan Type:  
     O-linked (other)
Compartment:  
     
Substrate:  
     Ser
Product:  
     Glc(a1-?)Ser
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data