Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
---|
Pathway figs |
---|
Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
---|
H2O | + |
|
→ |
|
+ |
|
• N-acetylglucosaminidase hydrolyzes GlcNAc from glycans in lysosomes. Involved in the degradation of heparan sulfates.
• Deficiencies in NAGLU causes Sanfilippo disease, also called mucopolysaccharosis type III. This disease is characterized by congitive declilne throughout and hyperactivity. Mutations in NAGLU causes death between 20 and 30 years of age.
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
|
|
|
|
|
NAGLU/hsa-miR-4483 |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...CCCUCCACC
ACCACCCA
...
3' GUUGUUGUC UGGUGGG G |
8mer | 166-173 | -0.272 | 97.0 | -0.272 | 98.0 | noncon |