SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
HGSNAT



General Information
Gene Symbol:   
HGSNAT
Protein name:   
Heparan-alpha-glucosaminide N-acetyltransferase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.3.1.78
Organs:   
Reaction (SNFG):   

GlcN(a1-4) → GlcNAc(a1-4)
Reaction (IUBMB):   
No specified reaction.
About

• Lysosomal acetyltransferase that acetylates the non-reducing terminal GlcNS into GlcNAc
• Here acetyl-CoA donates the acetyl group to a histidine residue in the cytoplasmic domain of the N-acetyltransferase. The acetyl gp. then becomes available in the luminal side of the lysosomal membrane, where the transfer occurs to form GlcNAc on the degrading HS chains. The action of exo-glucosaminidases follows to remove the terminal GlcNAc.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024096
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q68CP4 
NCBI GeneID:   
138050
GlyMap GeneID:   
138050
DNA aRefSeq:   
NM_152419.2 
Protein RefSeq:   
NP_689632.2 
BRENDA:   
Kinetic info.
OMIM number:   
610453
GeneCards database:   
HGSNAT
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcN(a1-4)
Product:  
     GlcNAc(a1-4)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data