Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• Lysosomal acetyltransferase that acetylates the non-reducing terminal GlcNS into GlcNAc
• Here acetyl-CoA donates the acetyl group to a histidine residue in the cytoplasmic domain of the N-acetyltransferase. The acetyl gp. then becomes available in the luminal side of the lysosomal membrane, where the transfer occurs to form GlcNAc on the degrading HS chains. The action of exo-glucosaminidases follows to remove the terminal GlcNAc.