Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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→ |
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• Beta hexosaminidase A and B interact with one another to degrade the GM2 ganglioside in lysosomes by removing GalNAc. These enzymes are important for regulating glycolipid homeostasis in the central nervous system.
• Defects in HEXA result in Tay Sachs disease, a condition which results in the buildup of lipids in the brain. This results in seizures, paralysis, and eventually death at an early age.
• HAEXA/B also facilitate glycoproteins (N- and O-) and keratin sulfate degradation
ER | Cis- | Medial- | Trans- | TGN |
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HEXA/hsa-miR-149-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AGCUAUGUCACUC
CCCUCCCA
...
3' CGUGUCGGGGGCA GGGAGGG A |
8mer | 355-362 | -0.261 | 94.0 | -0.044 | 62.0 | noncon | |
5'...CUUCCAUCCCCCU
CCUCCCA
A...
3' CGUGUCGGGGGCAG GGAGGG A |
7mer-A1 | 1351-1357 | -0.202 | 88.0 | -0.025 | 54.0 | noncon | |
5'...UACUCAUCCACCU
CCCUCCC
C...
3' CGUGUCGGGGGCA GGGAGGG A |
7mer-m8 | 549-555 | -0.195 | 87.0 | -0.033 | 58.0 | noncon | |
5'...CCGCCCGCCUUGG
CCUCCCA
A...
3' CGUGUCGGGGGCAG GGAGGG A |
7mer-A1 | 1092-1098 | -0.119 | 71.0 | -0.015 | 47.0 | noncon | |
5'...UCACUUGUCUUGG
CCUCCCA
A...
3' CGUGUCGGGGGCAG GGAGGG A |
7mer-A1 | 1227-1233 | -0.093 | 63.0 | -0.012 | 45.0 | noncon |