Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (firstname.lastname@example.org), Yusen Zhou (email@example.com) or Ted Groth (firstname.lastname@example.org).
• Synthesizes GDP-mannose from mannose 1 phosphate and GTP.
• Knowledge of GMPPA and B is subsumed based on porcupine enzyme activity and the homology of porcupine and GMPPA and B structures.
• GDP-mannose is a critical reactant for sugar nucleotide synthesis and glycosylation, as it can be directly used in the synthesis of N-linked glycans and can be metabolized into other sugar nucleotide donors.