Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ | UDP |
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+ | UDP |
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+ | UDP |
• This is C2GnT-2 or C2GnT-M (mucin type) that is the only enzyme acting as core-4 GlcNAcT.
• It acts in concert with B3GNT6 (core-3 synthase) to form core-4 structures on O-linked glycans.
• Additionally, GCNT3 also exhibits core2 and I-branching activity [mainly dIGnT on GlcNAc(β1-3)Gal(β1-4)GlcNAc(β1) substrates].
• Expressed in colon, gall bladder, intestine, stomach and duodenum.
• Physiological outcomes of missing this enzymes in mouse is relatively mild, though its expression is reduced during colorectal cancer cell proliferation and it may play a role during certain microbial infections.
ER | Cis- | Medial- | Trans- | TGN |
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GCNT3/hsa-miR-5591-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...UGCUAUUAGAGUG
UGGGUAA
G...
3' ACCCUCGAUUCGAU ACCCAU A |
7mer-A1 | 141-147 | -0.287 | 95.0 | -0.287 | 97.0 | noncon |