Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ |
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→ |
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+ | UDP |
• This is the β1,6-N-acetylglucosaminyltransferase or IGnT enzyme, forming the GlcNAcβ1-3(GlcNAcβ1-6)Galβ1-3GalNAcα1-R branch from the linear GlcNAcβ1-3Galβ1-3GalNAcα1-R lactosamine structure.
• In humans, GCNT2 is expressed as three spliced variants IGnTA, IGnTB and IGnTC.
• GCNT2 is overexpressed in highly metastatic breast cancer cell lines and basal-like breast tumor samples. Thus, GCNT2 expression correlates with metastatic phenotype of tumors.
• GCNT2 also enhances cell detachment, adhesion to endothelial cells, cell migration and invasion in vitro, and lung metastasis of breast cancer cells in vivo.
ER | Cis- | Medial- | Trans- | TGN |
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GCNT2/hsa-miR-3940-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AAUAUAAAAAUUAG
CCGGGCU
U...
3' UUCACCCGACCCUA GGCCCGA C |
7mer-m8 | 2270-2276 | -0.339 | 92.0 | -0.339 | 94.0 | noncon |