Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (firstname.lastname@example.org), Yusen Zhou (email@example.com) or Ted Groth (firstname.lastname@example.org).
• This is C2GnT-1 or C2GnT-L (leukocyte type) or core-2 GlcNAcT that forms the core-2 branch on O-glycans. It is widely expressed in human leukocytes and also other tissue.
• Its level is low in naive T-cells but increases upon T-cell activation.
• C2GnT-I upregulation also promotes metastasis in colorectral, lung and prostate cancer.
• C2GnT-I is a major contributor to L- and P-selectin binding during inflammation.
• Addition of sulfotransferase activity can result in the formation of 6-sulfo sialyl Lex structures on these core-2 glycans that act as L-selectin ligands in the HEV.
• GCNT1 is over-expressed in some diseases Wiskott-Aldrich syndrome (WAS), leukemia and AIDS. This contributes to immunodeficient conditions due to abherent T-cell function.
• Core2 branch is a scaffold for the subsequent production of lactosamine disaccharide repeat, poly-N-acetyllactosamine (Galβ1-4GlcNAc)n which is a ligand for galectin-3.
• Core-2 branch in general adds bulk to the O-glyans and this may reduce other interactions like TRAIL binding to DR4-- thus it is immunomodulatory.