Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
---|
Pathway figs |
---|
Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
---|
|
+ | Ser | → |
|
+ | UDP |
|
+ | Thr | → |
|
+ | UDP |
• ppGalNAc-T1 is localized throughout the Golgi
• Mutations in ppGalNAcT activity can result in various diseases.
• ppGalNAc-T2 and ppGalNAc-T3 were more abundant in the trans and medial Golgi.
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
|
|
|
|
|
GALNT1/hsa-miR-335-3p |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...AGAAUACUGAGACA
AUGAAAAA
...
3' CCAGUCCUCGUUAU UACUUUU U |
8mer | 285-292 | -0.352 | 99.0 | -0.352 | 99.0 | noncon | |
5'...UUGGGAAGAAAAGA
AUGAAAAA
...
3' CCAGUCCUCGUUAU UACUUUU U |
8mer | 2179-2186 | -0.144 | 97.0 | -0.001 | 46.0 | noncon | |
5'...CCAGAUUCAGAAUC
AUGAAAA
C...
3' CCAGUCCUCGUUAU UACUUUU U |
7mer-m8 | 477-483 | -0.088 | 94.0 | -0.081 | 95.0 | noncon | |
5'...UGGCAAAUACAUAU
AUGAAAA
U...
3' CCAGUCCUCGUUAU UACUUUU U |
7mer-m8 | 3225-3231 | -0.075 | 92.0 | 0.0 | 45.0 | noncon | |
5'...AGAAAAAAUGAAGG
AUGAAAAA
...
3' CCAGUCCUCGUUAU UACUUUU U |
8mer | 2366-2373 | -0.062 | 91.0 | 0.0 | 44.0 | noncon | |
5'...UGCUGAAAUUGAGC
UGAAAAA
A...
3' CCAGUCCUCGUUAUU ACUUUU U |
7mer-A1 | 702-708 | -0.041 | 87.0 | -0.038 | 90.0 | noncon |