FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALC



General Information
Gene Symbol:   
GALC
Protein name:   
Galactocerebrosidase
Enzyme Class:   
Glycosidase
CAZy Family:   
GH59
E.C. No:   
3.2.1.46
Organs:   
Reaction (SNFG):   
GALC
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Hydrolyzes galactosylceramide on glycolipids.
• Deficiency of this enzyme activity results in Krabbe disease.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1660662
Related Database
Organism:   
Homo sapiens
Uniprot:   
P54803 
NCBI GeneID:   
2581
GlyMap GeneID:   
2581
DNA aRefSeq:   
NM_000153.3 
Protein RefSeq:   
NP_000144.2 
BRENDA:   
Kinetic info.
OMIM number:   
-
GeneCards database:   
GALC
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Gal(b1-r):Cer
Product:  
     Cer
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-1207-3p 1245-1252 -0.434 99.0 -0.434 99.0 noncon
hsa-miR-4458 605-611 -0.432 96.0 -0.432 97.0 con
hsa-miR-4529-3p 954-961 -0.431 97.0 -0.431 98.0 noncon
hsa-let-7f-5p 605-611 -0.431 96.0 -0.431 97.0 con
hsa-miR-3614-5p 1234-1241 -0.427 99.0 -0.427 99.0 noncon
hsa-miR-6825-5p 1670-1677 -0.424 97.0 -0.02 33.0 noncon
hsa-miR-98-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7a-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7g-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7e-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7i-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7b-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-let-7c-5p 605-611 -0.42 96.0 -0.42 97.0 con
hsa-miR-4500 605-611 -0.42 96.0 -0.42 97.0 con
hsa-miR-8058 953-960 -0.416 98.0 -0.416 98.0 noncon
hsa-miR-4474-5p 103-110 -0.412 98.0 -0.412 98.0 noncon
hsa-miR-5009-5p 953-960 -0.411 98.0 -0.411 99.0 noncon
hsa-let-7d-5p 605-611 -0.41 95.0 -0.41 96.0 con
hsa-miR-196b-5p 604-610 -0.362 97.0 -0.362 98.0 con
hsa-miR-196a-5p 604-610 -0.362 97.0 -0.362 98.0 con
hsa-miR-4418 623-630 -0.362 99.0 -0.362 99.0 noncon
hsa-miR-509-5p 623-630 -0.357 99.0 -0.357 99.0 noncon
hsa-miR-3192-5p 911-918 -0.351 99.0 -0.351 99.0 noncon
hsa-miR-92a-2-5p 1673-1680 -0.351 98.0 -0.017 51.0 noncon
hsa-miR-509-3-5p 623-630 -0.333 99.0 -0.333 99.0 noncon
hsa-miR-4777-5p 1070-1077 -0.329 98.0 -0.329 98.0 noncon
hsa-miR-4795-5p 483-490 -0.324 97.0 -0.324 97.0 noncon
hsa-miR-760 60-67 -0.322 95.0 -0.322 96.0 con
hsa-miR-222-3p 1035-1042 -0.318 95.0 -0.318 97.0 noncon
hsa-miR-221-3p 1035-1042 -0.318 95.0 -0.318 97.0 noncon
hsa-miR-6750-5p 224-231 -0.312 98.0 -0.312 98.0 noncon
hsa-miR-140-5p 700-707 -0.312 96.0 -0.312 97.0 noncon
hsa-miR-4524a-5p 297-304 -0.31 94.0 -0.31 96.0 noncon
hsa-miR-4524b-5p 297-304 -0.31 94.0 -0.31 96.0 noncon
hsa-miR-122-5p 1371-1378 -0.307 97.0 -0.015 54.0 noncon
hsa-miR-6822-5p 224-231 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-140-3p.1 156-163 -0.295 97.0 -0.295 98.0 noncon
hsa-miR-7109-3p 94-100 -0.293 97.0 -0.293 98.0 noncon
hsa-miR-219a-2-3p 1328-1335 -0.292 97.0 -0.014 50.0 noncon
hsa-miR-8075 1565-1572 -0.286 94.0 -0.014 38.0 noncon
hsa-miR-8065 1312-1318 -0.279 91.0 -0.279 94.0 noncon
hsa-miR-539-3p 1645-1652 -0.277 93.0 -0.014 34.0 noncon
hsa-miR-7155-5p 1403-1410 -0.274 96.0 -0.013 45.0 noncon
hsa-miR-4422 498-505 -0.273 99.0 -0.273 99.0 noncon
hsa-miR-4255 457-464 -0.268 97.0 -0.268 98.0 noncon
hsa-miR-4314 912-919 -0.264 94.0 -0.264 96.0 noncon
hsa-miR-3154 39-45 -0.258 96.0 -0.258 97.0 noncon
hsa-miR-3152-3p 611-617 -0.25 95.0 -0.25 96.0 noncon