GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
DPM2



General Information
Gene Symbol:   
DPM2
Protein name:   
Dolichol phosphate-mannose biosynthesis regulatory protein
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• This is an essential regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex, which includes DPM1 and DPM3.
• This protein is also part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of GlcNAc UDP-GlcNAc to phosphatidylinositol during first step of GPI biosynthesis

Related Pathway
KEGG ORTHOLOGY:   
K09658
KEGG Pathway:   
ko00510  ko00563  ko01100 
Reactome:   
R-HSA-162699
Related Database
Organism:   
Homo sapiens
Uniprot:   
O94777 
NCBI GeneID:   
8818
GlyMap GeneID:   
8818
DNA aRefSeq:   
NM_003863.3 
Protein RefSeq:   
NP_003854.1 
BRENDA:   
Kinetic info.
OMIM number:   
603564
GeneCards database:   
DPM2
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6777-5p 166-173 -0.677 99.0 -0.677 99.0 noncon
hsa-miR-6889-5p 166-173 -0.651 99.0 -0.651 99.0 noncon
hsa-miR-133a-3p.1 54-61 -0.647 99.0 -0.647 99.0 noncon
hsa-miR-185-3p 429-436 -0.634 99.0 -0.629 99.0 noncon
hsa-miR-6880-5p 398-405 -0.628 99.0 -0.628 99.0 noncon
hsa-miR-4652-5p 123-130 -0.62 99.0 -0.62 99.0 noncon
hsa-miR-6796-5p 439-446 -0.605 99.0 -0.6 99.0 noncon
hsa-miR-6742-5p 438-445 -0.602 99.0 -0.597 99.0 noncon
hsa-miR-4763-3p 281-288 -0.586 99.0 -0.586 99.0 noncon
hsa-miR-6872-3p 132-139 -0.58 99.0 -0.58 99.0 noncon
hsa-miR-1207-5p 281-288 -0.576 99.0 -0.576 99.0 noncon
hsa-miR-4693-3p 269-276 -0.534 99.0 -0.534 99.0 noncon
hsa-miR-1286 114-121 -0.518 99.0 -0.518 99.0 noncon
hsa-miR-3689a-3p 258-265 -0.509 99.0 -0.509 99.0 noncon
hsa-miR-22-3p 407-413 -0.508 99.0 -0.508 99.0 con
hsa-miR-1271-3p 86-93 -0.506 99.0 -0.506 99.0 noncon
hsa-miR-550a-3-5p 86-93 -0.506 99.0 -0.506 99.0 noncon
hsa-miR-550a-5p 86-93 -0.506 99.0 -0.506 99.0 noncon
hsa-miR-1273h-5p 258-265 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-6779-5p 258-265 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-3689c 258-265 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-3689b-3p 258-265 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-30b-3p 258-265 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-1910-5p 475-482 -0.497 99.0 -0.493 99.0 noncon
hsa-miR-6780a-5p 258-265 -0.496 99.0 -0.496 99.0 noncon
hsa-miR-1254 84-91 -0.495 99.0 -0.495 99.0 noncon
hsa-miR-3934-5p 144-151 -0.493 99.0 -0.493 99.0 noncon
hsa-miR-4260 562-569 -0.477 98.0 -0.472 99.0 noncon
hsa-miR-766-5p 395-402 -0.471 99.0 -0.471 99.0 noncon
hsa-miR-542-3p 330-337 -0.469 99.0 -0.469 99.0 noncon
hsa-miR-3116 84-91 -0.469 99.0 -0.469 99.0 noncon
hsa-miR-1205 116-123 -0.467 99.0 -0.467 99.0 noncon
hsa-miR-7106-5p 257-264 -0.465 99.0 -0.465 99.0 noncon
hsa-miR-6761-5p 271-278 -0.463 99.0 -0.463 99.0 noncon
hsa-miR-6852-5p 487-494 -0.461 99.0 -0.457 99.0 noncon
hsa-miR-6815-5p 285-291 -0.451 99.0 -0.451 99.0 noncon
hsa-miR-6865-5p 285-291 -0.451 99.0 -0.451 99.0 noncon
hsa-miR-1291 237-243 -0.441 98.0 -0.441 98.0 noncon
hsa-miR-377-5p 263-270 -0.436 99.0 -0.436 99.0 noncon
hsa-miR-2355-5p 468-475 -0.428 99.0 -0.425 99.0 noncon
hsa-miR-1225-3p 503-510 -0.426 98.0 -0.422 98.0 noncon
hsa-miR-6734-3p 471-478 -0.423 98.0 -0.42 99.0 noncon
hsa-miR-3135b 44-51 -0.419 99.0 -0.419 99.0 noncon
hsa-miR-185-3p 560-567 -0.41 96.0 -0.406 96.0 noncon
hsa-miR-362-3p 616-622 -0.401 99.0 -0.397 99.0 noncon
hsa-miR-4689 98-105 -0.394 99.0 -0.394 99.0 noncon
hsa-miR-6778-5p 174-180 -0.389 97.0 -0.389 98.0 noncon
hsa-miR-4667-3p 192-199 -0.388 98.0 -0.388 98.0 noncon
hsa-miR-7847-3p 397-403 -0.377 97.0 -0.377 98.0 noncon
hsa-miR-6780b-5p 321-327 -0.377 97.0 -0.377 97.0 noncon
hsa-miR-6810-5p 124-130 -0.375 98.0 -0.375 98.0 noncon
hsa-miR-329-3p 616-622 -0.368 99.0 -0.364 99.0 noncon
hsa-miR-3150b-3p 544-551 -0.368 98.0 -0.364 99.0 noncon
hsa-miR-6086 263-270 -0.366 99.0 -0.366 99.0 noncon
hsa-miR-6775-3p 237-243 -0.365 96.0 -0.365 97.0 noncon
hsa-miR-31-5p 311-317 -0.362 97.0 -0.362 98.0 noncon
hsa-miR-4316 315-321 -0.362 98.0 -0.362 99.0 noncon
hsa-miR-1205 71-78 -0.36 99.0 -0.36 99.0 noncon
hsa-miR-1233-5p 174-180 -0.356 96.0 -0.356 97.0 noncon
hsa-miR-4784 544-551 -0.352 98.0 -0.348 98.0 noncon
hsa-miR-6805-5p 161-167 -0.35 93.0 -0.35 95.0 noncon
hsa-miR-1299 181-188 -0.35 98.0 -0.35 98.0 noncon
hsa-miR-4779 325-331 -0.346 98.0 -0.346 98.0 noncon
hsa-miR-555 417-423 -0.34 95.0 -0.34 97.0 noncon
hsa-miR-6882-3p 406-412 -0.338 96.0 -0.338 97.0 noncon
hsa-miR-4747-3p 239-245 -0.337 98.0 -0.337 99.0 noncon
hsa-miR-1193 376-382 -0.334 98.0 -0.334 98.0 noncon
hsa-miR-4283 159-165 -0.334 95.0 -0.334 96.0 noncon
hsa-miR-4725-3p 321-327 -0.333 96.0 -0.333 96.0 noncon
hsa-miR-92a-1-5p 261-267 -0.329 93.0 -0.329 95.0 noncon
hsa-miR-4281 54-60 -0.328 99.0 -0.328 99.0 noncon
hsa-miR-6858-5p 98-105 -0.326 98.0 -0.326 99.0 noncon
hsa-miR-6085 25-31 -0.325 96.0 -0.325 97.0 noncon
hsa-miR-5094 609-615 -0.323 98.0 -0.32 98.0 noncon
hsa-miR-370-5p 376-382 -0.32 97.0 -0.32 98.0 noncon
hsa-miR-6846-5p 160-166 -0.316 90.0 -0.316 92.0 noncon
hsa-miR-6848-5p 160-166 -0.316 90.0 -0.316 92.0 noncon
hsa-miR-4459 326-332 -0.316 98.0 -0.316 98.0 noncon
hsa-miR-4751 255-261 -0.313 95.0 -0.313 96.0 noncon
hsa-miR-6851-5p 222-228 -0.311 95.0 -0.311 96.0 noncon
hsa-miR-6758-5p 380-386 -0.311 98.0 -0.311 98.0 noncon
hsa-miR-6889-3p 88-94 -0.311 96.0 -0.311 97.0 noncon
hsa-miR-6813-5p 25-31 -0.31 96.0 -0.31 97.0 noncon
hsa-miR-4741 428-434 -0.309 97.0 -0.307 98.0 noncon
hsa-miR-1294 265-271 -0.304 96.0 -0.304 97.0 noncon
hsa-miR-7704 437-443 -0.303 96.0 -0.301 96.0 noncon
hsa-miR-7150 282-288 -0.3 96.0 -0.3 97.0 noncon
hsa-miR-7108-5p 366-372 -0.294 97.0 -0.294 98.0 noncon
hsa-miR-6764-5p 296-302 -0.292 98.0 -0.292 98.0 noncon
hsa-miR-6856-5p 380-386 -0.29 97.0 -0.29 98.0 noncon
hsa-miR-4270 279-285 -0.289 97.0 -0.289 97.0 noncon
hsa-miR-1295a 240-246 -0.287 94.0 -0.287 96.0 noncon
hsa-miR-4532 520-526 -0.285 92.0 -0.282 93.0 noncon
hsa-miR-491-5p 439-445 -0.284 94.0 -0.282 95.0 noncon
hsa-miR-4667-5p 432-438 -0.284 95.0 -0.282 96.0 noncon
hsa-miR-4271 321-327 -0.282 96.0 -0.282 96.0 noncon
hsa-miR-3191-3p 124-130 -0.282 95.0 -0.282 95.0 noncon
hsa-miR-6891-5p 224-230 -0.279 96.0 -0.279 97.0 noncon
hsa-miR-1915-3p 296-302 -0.278 97.0 -0.278 98.0 noncon
hsa-miR-4501 332-338 -0.278 96.0 -0.278 98.0 noncon
hsa-miR-133b 55-61 -0.275 90.0 -0.275 93.0 noncon
hsa-miR-542-5p 167-173 -0.275 90.0 -0.275 93.0 noncon
hsa-miR-133a-3p.2 55-61 -0.275 90.0 -0.275 93.0 noncon
hsa-miR-4425 260-266 -0.274 90.0 -0.274 93.0 noncon
hsa-miR-99a-3p 138-144 -0.274 98.0 -0.274 98.0 noncon
hsa-miR-4302 608-614 -0.273 96.0 -0.27 97.0 noncon
hsa-miR-4489 569-575 -0.272 95.0 -0.269 96.0 noncon
hsa-miR-3690 83-89 -0.271 96.0 -0.271 97.0 noncon
hsa-miR-765 396-402 -0.271 93.0 -0.271 94.0 noncon
hsa-miR-5001-5p 23-29 -0.27 90.0 -0.27 92.0 noncon
hsa-miR-6801-5p 597-603 -0.269 95.0 -0.266 96.0 noncon
hsa-miR-4522 120-126 -0.269 95.0 -0.269 96.0 noncon
hsa-miR-6753-3p 482-488 -0.268 93.0 -0.266 95.0 noncon
hsa-miR-6515-5p 42-48 -0.268 93.0 -0.268 95.0 noncon
hsa-miR-4441 279-285 -0.268 96.0 -0.268 97.0 noncon
hsa-miR-3144-5p 124-130 -0.265 90.0 -0.265 92.0 noncon
hsa-miR-6754-5p 279-285 -0.264 96.0 -0.264 97.0 noncon
hsa-miR-125a-3p 145-151 -0.264 96.0 -0.264 97.0 noncon
hsa-miR-4489 430-436 -0.262 94.0 -0.26 96.0 noncon
hsa-miR-7974 427-433 -0.262 91.0 -0.26 93.0 noncon
hsa-miR-4696 310-316 -0.262 96.0 -0.262 97.0 noncon
hsa-miR-125a-5p 235-241 -0.261 93.0 -0.261 95.0 noncon
hsa-miR-4319 235-241 -0.261 94.0 -0.261 95.0 noncon
hsa-miR-125b-5p 235-241 -0.261 93.0 -0.261 95.0 noncon
hsa-miR-6894-5p 396-402 -0.259 96.0 -0.259 97.0 noncon
hsa-miR-3689d 222-228 -0.259 96.0 -0.259 97.0 noncon
hsa-miR-7107-3p 482-488 -0.257 92.0 -0.255 94.0 noncon
hsa-miR-7154-3p 256-262 -0.254 95.0 -0.254 96.0 noncon
hsa-miR-4433b-5p 589-595 -0.251 92.0 -0.249 94.0 noncon
hsa-miR-99b-3p 138-144 -0.25 97.0 -0.25 98.0 noncon