Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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PAPS | + |
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+ | PAP |
PAPS | + |
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→ |
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+ | PAP |
PAPS | + |
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→ |
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+ | PAP |
PAPS | + |
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+ | PAP |
• Chondroitin sulfate chains are composed of GlcAβ1-3GalNAcβ1-4 repeating unit. Various sulfotransferases, CHST3, 7, 11, 12, 13, 14, 15, and UST, sulfate either GalNAc and GlcA residues. CS are a major functional component of aggrecan, and needed for cartilage formation and maintenance.
• Dermatan 4-O sulfotransferase 1 (D4ST1) is the CS/DS 4-O-sulfotransferase responsible for the sulfation of GalNAc in blocks of IdoA-GalNAc-IdoA.
• It acts both nearly fully or partially desulfated DS, but not on CS.
• Chst14/D4st1-deficient mice showed growth retardation as well as multiple system abnormalities including neurological changes.
ER | Cis- | Medial- | Trans- | TGN |
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CHST14/hsa-miR-608 |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'... GAUCCCCCAUUUAU
CCACCCCA
...
3' UGCCUCGACAGGGUUGU GGUGGGG A |
8mer | 417-424 | -0.582 | 98.0 | -0.582 | 99.0 | noncon |