GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B4GAT1



General Information
Gene Symbol:   
B4GAT1
Protein name:   
Beta-1,4-glucuronyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT49
E.C. No:   
2.4.1.*
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Acts as priming enzyme during the extension of O-Man type glycans on DAG1

Related Pathway
KEGG ORTHOLOGY:   
K21032
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2022854
Related Database
Organism:   
Homo sapiens
Uniprot:   
O43505 
NCBI GeneID:   
11041
GlyMap GeneID:   
11041
DNA aRefSeq:   
NM_006876.2 
Protein RefSeq:   
NP_006867.1 
BRENDA:   
Kinetic info.
OMIM number:   
605517
GeneCards database:   
B4GAT1
Enzyme Specificity
Glycan Type:  
     O-linked (other)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Xyl(b1-4)
Product:  
     GlcA(b1-4)Xyl(b1-4)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data