GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B3GALT6



General Information
Gene Symbol:   
B3GALT6
Protein name:   
Beta-1,3-galactosyltransferase 6
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT31
E.C. No:   
2.4.1.134
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Encodes for the UDP-Gal:βGalβ1-4Xyl β1,3-galactosyltransferase. This is the third step of the GAG biosynthesis after Xyl1/2 and B4GalT7.

Related Pathway
KEGG ORTHOLOGY:   
K00734
KEGG Pathway:   
ko00532  ko00534  ko01100 
Reactome:   
R-HSA-1971475
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q96L58 
NCBI GeneID:   
126792
GlyMap GeneID:   
126792
DNA aRefSeq:   
NM_080605.3 
Protein RefSeq:   
NP_542172.2 
BRENDA:   
Kinetic info.
OMIM number:   
615291
GeneCards database:   
B3GALT6
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Gal(b1-4)Xyl(b1-?)Ser
Product:  
     Gal(b1-3)Gal(b1-4)Xyl(b1-?)Ser
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3193 565-572 -0.627 99.0 -0.045 42.0 noncon
hsa-miR-3917 1656-1663 -0.584 99.0 -0.017 33.0 noncon
hsa-miR-4449 20-27 -0.543 97.0 -0.543 97.0 noncon
hsa-miR-4790-5p 848-855 -0.498 97.0 -0.034 45.0 noncon
hsa-miR-1199-3p 228-235 -0.482 98.0 -0.482 98.0 noncon
hsa-miR-486-3p 1776-1783 -0.468 97.0 -0.001 16.0 noncon
hsa-miR-7108-3p 1144-1151 -0.456 97.0 -0.014 34.0 noncon
hsa-miR-486-3p 707-714 -0.411 95.0 -0.029 39.0 noncon
hsa-miR-6803-5p 1663-1670 -0.411 98.0 -0.012 34.0 noncon
hsa-miR-486-3p 886-893 -0.407 95.0 -0.029 39.0 noncon
hsa-miR-604 102-109 -0.405 99.0 -0.405 99.0 noncon
hsa-miR-4462 288-294 -0.402 95.0 -0.402 96.0 noncon
hsa-miR-6767-5p 317-323 -0.395 94.0 -0.395 96.0 noncon
hsa-miR-6751-5p 1663-1670 -0.382 97.0 -0.012 33.0 noncon
hsa-miR-4670-5p 117-123 -0.375 90.0 -0.375 92.0 noncon
hsa-miR-4726-3p 1459-1466 -0.363 99.0 -0.011 59.0 noncon
hsa-miR-561-5p 821-828 -0.356 98.0 -0.026 51.0 noncon
hsa-miR-6719-3p 514-521 -0.355 98.0 -0.028 67.0 noncon
hsa-miR-1976 567-574 -0.35 98.0 -0.027 76.0 noncon
hsa-miR-3929 1739-1746 -0.342 99.0 -0.01 66.0 noncon
hsa-miR-4329 323-330 -0.341 99.0 -0.341 99.0 noncon
hsa-miR-6809-5p 865-872 -0.34 96.0 -0.024 51.0 noncon
hsa-miR-106b-3p 467-473 -0.339 90.0 -0.028 31.0 noncon
hsa-miR-4419b 1739-1746 -0.334 99.0 -0.009 65.0 noncon
hsa-miR-5190 611-618 -0.333 98.0 -0.024 77.0 noncon
hsa-miR-423-5p 830-836 -0.326 94.0 -0.024 49.0 noncon
hsa-miR-6767-5p 132-138 -0.326 90.0 -0.326 92.0 noncon
hsa-miR-4764-5p 817-823 -0.325 95.0 -0.024 45.0 noncon
hsa-miR-6801-5p 1705-1711 -0.317 97.0 -0.009 34.0 noncon
hsa-miR-3184-5p 830-836 -0.315 94.0 -0.023 48.0 noncon
hsa-miR-4523 478-484 -0.314 94.0 -0.026 30.0 noncon
hsa-miR-4478 1739-1746 -0.31 99.0 -0.009 64.0 noncon
hsa-miR-1203 1057-1063 -0.31 90.0 -0.01 23.0 noncon
hsa-miR-1471 928-934 -0.31 92.0 -0.01 15.0 noncon
hsa-miR-3610 1450-1456 -0.309 91.0 -0.01 18.0 noncon
hsa-miR-6882-3p 1113-1120 -0.3 95.0 -0.009 31.0 noncon
hsa-miR-338-5p 433-440 -0.297 99.0 -0.292 99.0 noncon
hsa-miR-1207-5p 1442-1449 -0.297 95.0 -0.009 42.0 noncon
hsa-miR-3124-3p 501-508 -0.296 97.0 -0.025 67.0 noncon
hsa-miR-4435 584-590 -0.29 95.0 -0.023 58.0 noncon
hsa-miR-7702 1678-1685 -0.286 95.0 -0.009 38.0 noncon
hsa-miR-4648 980-986 -0.282 95.0 -0.009 41.0 noncon
hsa-miR-4258 1145-1151 -0.276 91.0 -0.009 24.0 noncon
hsa-miR-4763-3p 1442-1449 -0.275 94.0 -0.009 41.0 noncon
hsa-miR-4725-5p 1026-1033 -0.274 92.0 -0.009 31.0 noncon
hsa-miR-593-5p 525-531 -0.27 90.0 -0.022 36.0 noncon
hsa-miR-6085 829-835 -0.268 94.0 -0.02 36.0 noncon
hsa-miR-7107-5p 1245-1251 -0.264 92.0 -0.008 30.0 noncon
hsa-miR-4795-5p 1700-1706 -0.262 94.0 -0.008 41.0 noncon
hsa-miR-1243 1687-1693 -0.261 95.0 -0.008 38.0 noncon
hsa-miR-7114-3p 1173-1180 -0.258 93.0 -0.008 41.0 noncon
hsa-miR-6839-5p 1686-1692 -0.256 95.0 -0.008 43.0 noncon
hsa-miR-602 554-560 -0.255 91.0 -0.021 45.0 noncon
hsa-miR-4682 402-408 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-6813-5p 829-835 -0.253 93.0 -0.019 40.0 noncon