Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ | UDP |
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+ | UDP |
• Produces type 1 chain linkage in glycolipids and core-3 O-glycans, but not N-linked glycoproteins.
• May be an important enzyme forming CA19-9 in colon cancer. Beyond serving as a biomarker, CA19-9 also promotes pancreatitis and pancreatic cancer (in mice).
• B3GalT5 efficiently transfers Gal to the GlcNAc of the glycolipid Lc3Cer and to the terminal GalNAc residue of the globoside Gb4.
• It may thus contribute to the formation of CA 19-9, SSEA-3 and elongated core-3 O-glycans.
• Expression is restricted to the colorectum, small intestine, stomach, and pancreas.
ER | Cis- | Medial- | Trans- | TGN |
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B3GALT5/hsa-miR-5001-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'... AUAAACUCUUCAGU
CCAGCCCA
...
3' UCGAGGCGGCGACUCA GGUCGGG A |
8mer | 8651-8658 | -0.289 | 92.0 | -0.289 | 94.0 | noncon | |
5'... UAACUGCCCCACAU
CCAGCCCA
...
3' UCGAGGCGGCGACUCA GGUCGGG A |
8mer | 3613-3620 | -0.286 | 92.0 | -0.286 | 93.0 | noncon | |
5'... AUACACGCCUACAC
CCAGCCC
C...
3' UCGAGGCGGCGACUCA GGUCGGG A |
7mer-m8 | 2816-2822 | -0.162 | 73.0 | -0.162 | 80.0 | noncon | |
5'... ACAGCAUCAGCUCA
CAGCCCA
C...
3' UCGAGGCGGCGACUCAG GUCGGG A |
7mer-A1 | 1854-1860 | -0.162 | 73.0 | -0.162 | 80.0 | noncon | |
5'... CAAGUGUCCAAUGG
CAGCCCA
A...
3' UCGAGGCGGCGACUCAG GUCGGG A |
7mer-A1 | 8608-8614 | -0.155 | 71.0 | -0.155 | 79.0 | noncon | |
5'... UGUGCGCCUGUCCU
CCAGCCC
G...
3' UCGAGGCGGCGACUCA GGUCGGG A |
7mer-m8 | 4758-4764 | -0.103 | 58.0 | -0.103 | 69.0 | noncon | |
5'... UAGGAAGCUUGGGA
CCAGCCC
U...
3' UCGAGGCGGCGACUCA GGUCGGG A |
7mer-m8 | 8377-8383 | -0.093 | 55.0 | -0.093 | 67.0 | noncon | |
5'... UCCGCCUCCGGGUU
CCAGCCC
U...
3' UCGAGGCGGCGACUCA GGUCGGG A |
7mer-m8 | 6369-6375 | -0.088 | 54.0 | -0.088 | 66.0 | noncon | |
5'... CUGUCCUGCCCUGG
CCAGCCC
U...
3' UCGAGGCGGCGACUCA GGUCGGG A |
7mer-m8 | 8572-8578 | -0.075 | 50.0 | -0.075 | 62.0 | noncon |