Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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GalNAc(b1-4 [4S]) | → | GalNAc(b1-4) |
• Removes sulfate groups from chondroitin-4-sulfate(C4S) and regulates its degradation
• One of three human CS/DS exosulfatases: ARSB (4-O-sulfatase) (Bond et al., 1997), GALNS (6-O-sulfatase) (Rivera-Colon et al., 2012) and IDS (iduronate-2-O-sulfatase) (Demydchuk et al., 2017).
ER | Cis- | Medial- | Trans- | TGN |
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ARSB/hsa-miR-6720-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'... CACUGAAUCCUGGA
GGCUGGAA
...
3' GCGCCGCGGAUGGUC CCGACCU U |
8mer | 303-310 | -0.366 | 98.0 | -0.23 | 95.0 | noncon | |
5'... ACACUCCUGCUGUU
GGCUGGA
G...
3' GCGCCGCGGAUGGUC CCGACCU U |
7mer-m8 | 193-199 | -0.186 | 89.0 | -0.12 | 86.0 | noncon | |
5'... CAGGCACCCAAAUA
GCUGGAA
C...
3' GCGCCGCGGAUGGUCC CGACCU U |
7mer-A1 | 1492-1498 | -0.122 | 78.0 | -0.03 | 63.0 | noncon | |
5'... CGCUCUGUCACCCA
GGCUGGA
G...
3' GCGCCGCGGAUGGUC CCGACCU U |
7mer-m8 | 2572-2578 | -0.085 | 67.0 | -0.019 | 55.0 | noncon | |
5'... CUCACAAGGCUCUU
GGCUGGA
G...
3' GCGCCGCGGAUGGUC CCGACCU U |
7mer-m8 | 3519-3525 | -0.071 | 62.0 | -0.007 | 42.0 | noncon |