GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ALG10B



General Information
Gene Symbol:   
ALG10B
Protein name:   
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
2.4.1.256
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446193
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q5I7T1 
NCBI GeneID:   
144245
GlyMap GeneID:   
144245
DNA aRefSeq:   
NM_001013620.3 
Protein RefSeq:   
NP_001013642.1 
BRENDA:   
Kinetic info.
OMIM number:   
603313
GeneCards database:   
ALG10B
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     Glc(a1-3)Glc(a1-3)Man(a1-2)Man(a1-2)Man(a1-3)
Product:  
     Glc(a1-2)Glc(a1-3)Glc(a1-3)Man(a1-2)Man(a1-2)Man(a1-3)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4751 107-114 -0.422 98.0 -0.422 98.0 noncon
hsa-miR-4529-5p 672-679 -0.412 97.0 -0.412 98.0 noncon
hsa-miR-4482-5p 311-318 -0.389 98.0 -0.389 99.0 noncon
hsa-miR-1273c 7900-7907 -0.379 97.0 -0.339 97.0 noncon
hsa-miR-1827 6410-6417 -0.366 98.0 -0.327 97.0 noncon
hsa-miR-6503-3p 3761-3768 -0.353 98.0 -0.343 98.0 noncon
hsa-miR-4716-5p 78-85 -0.35 98.0 -0.35 99.0 noncon
hsa-miR-3130-5p 311-318 -0.339 98.0 -0.339 99.0 noncon
hsa-miR-4480 3240-3247 -0.335 97.0 -0.326 98.0 noncon
hsa-miR-126-3p.1 1302-1308 -0.33 90.0 -0.33 92.0 noncon
hsa-miR-6861-3p 7950-7957 -0.309 93.0 -0.277 94.0 noncon
hsa-miR-4256 7938-7945 -0.308 95.0 -0.276 96.0 noncon
hsa-miR-6802-5p 4242-4249 -0.304 92.0 -0.272 93.0 noncon
hsa-miR-628-3p 328-335 -0.302 96.0 -0.302 97.0 noncon
hsa-miR-423-5p 264-271 -0.302 93.0 -0.302 94.0 noncon
hsa-miR-4529-5p 3377-3384 -0.302 93.0 -0.294 95.0 noncon
hsa-miR-150-3p 430-437 -0.296 92.0 -0.296 95.0 noncon
hsa-miR-6845-5p 262-268 -0.296 91.0 -0.296 93.0 noncon
hsa-miR-4800-5p 7952-7959 -0.289 92.0 -0.259 93.0 noncon
hsa-miR-3184-5p 264-271 -0.286 92.0 -0.286 93.0 noncon
hsa-miR-193a-5p 1118-1125 -0.285 95.0 -0.285 96.0 noncon
hsa-miR-6841-3p 2680-2687 -0.283 94.0 -0.275 95.0 noncon
hsa-miR-1294 7489-7495 -0.282 95.0 -0.253 95.0 noncon
hsa-miR-365b-3p 5495-5501 -0.276 94.0 -0.248 95.0 noncon
hsa-miR-365a-3p 5495-5501 -0.276 94.0 -0.248 95.0 noncon
hsa-miR-610 5009-5016 -0.274 95.0 -0.246 95.0 noncon
hsa-miR-4708-5p 3987-3994 -0.27 96.0 -0.263 97.0 noncon
hsa-miR-6873-5p 7197-7204 -0.27 95.0 -0.242 95.0 noncon
hsa-miR-6734-5p 2335-2342 -0.266 90.0 -0.259 92.0 noncon
hsa-miR-4480 3436-3443 -0.259 95.0 -0.252 97.0 noncon
hsa-miR-7154-3p 1688-1695 -0.258 95.0 -0.251 96.0 noncon
hsa-miR-4786-3p 8379-8385 -0.257 94.0 -0.231 95.0 noncon
hsa-miR-3136-5p 8426-8433 -0.256 95.0 -0.23 95.0 noncon